Knockdown of neuron-specific enolase suppresses the proliferation and migration of NCI-H209 cells
Identifieur interne : 000701 ( Main/Exploration ); précédent : 000700; suivant : 000702Knockdown of neuron-specific enolase suppresses the proliferation and migration of NCI-H209 cells
Auteurs : Xia Liu [République populaire de Chine] ; Shousheng Liu [République populaire de Chine] ; Juan Fu [République populaire de Chine] ; Jinsheng Huang [République populaire de Chine] ; Chengyin Weng [République populaire de Chine] ; Xisheng Fang [République populaire de Chine] ; Mingmei Guan [République populaire de Chine] ; Yong Wu [République populaire de Chine] ; Lin Yang [République populaire de Chine] ; Guolong Liu [République populaire de Chine]Source :
- Oncology Letters [ 1792-1074 ] ; 2019.
Abstract
Neuron-specific enolase (NSE) is generally considered as a marker for diagnosis and evaluation of the response to therapy in small cell lung cancer (SCLC). However, the role of NSE in the progression of SCLC remains to be elucidated. In the present study, the functions of NSE in SCLC, in addition to the potential mechanisms, were investigated using a loss-of-function approach with NSE-targeting small interfering (si)RNA. The knockdown of NSE markedly decreased the proliferation of NCI-H209 cells, as indicated by MTT assay (P<0.05). Furthermore, the silencing of NSE resulted in the formation of smaller and fewer colonies compared with that in the control group (P<0.001). Flow cytometric analysis indicated that the silencing of NSE resulted in a decreased S-phase population among NCI-H209 cells (P<0.05). Transwell assay demonstrated that the silencing of NSE suppressed the migration of NCI-H209 cells (P<0.001). NCI-H209 cells transfected with NSE siRNA-1 or negative control were collected and the protein levels of metastasis-associated genes were detected using western blot analysis. The results indicated that the knockdown of NSE led to downregulation of the pro-metastatic gene vascular endothelial growth factor (VEGF; P<0.05) and the upregulation of metastasis suppressor genes NM23 and E-cadherin (P<0.05). Taken together, the results of the present study demonstrated that the silencing of NSE suppressed the migration, proliferation and colony formation ability of SCLC cells and decreased the S-phase population. In addition, the knockdown of NSE resulted in the upregulation of E-cadherin and NM23 and the downregulation of VEGF. Collectively, these results indicated that intracellular NSE may have an important role in the progression of SCLC.
Url:
DOI: 10.3892/ol.2019.10797
PubMed: 31611991
PubMed Central: 6781773
Affiliations:
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180</wicri:regionArea><wicri:noRegion>Guangdong 510180</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Mingmei" sort="Guan, Mingmei" uniqKey="Guan M" first="Mingmei" last="Guan">Mingmei Guan</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-10797">Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. 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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180</wicri:regionArea><wicri:noRegion>Guangdong 510180</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Lin" sort="Yang, Lin" uniqKey="Yang L" first="Lin" last="Yang">Lin Yang</name><affiliation wicri:level="1"><nlm:aff id="af5-ol-0-0-10797">Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515</wicri:regionArea><wicri:noRegion>Guangdong 510515</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Guolong" sort="Liu, Guolong" uniqKey="Liu G" first="Guolong" last="Liu">Guolong Liu</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-10797">Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. 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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180</wicri:regionArea><wicri:noRegion>Guangdong 510180</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Shousheng" sort="Liu, Shousheng" uniqKey="Liu S" first="Shousheng" last="Liu">Shousheng Liu</name><affiliation wicri:level="1"><nlm:aff id="af2-ol-0-0-10797">State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, Guangdong 510060</wicri:regionArea><wicri:noRegion>Guangdong 510060</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ol-0-0-10797">Department of General Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of General Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060</wicri:regionArea><wicri:noRegion>Guangdong 510060</wicri:noRegion></affiliation></author><author><name sortKey="Fu, Juan" sort="Fu, Juan" uniqKey="Fu J" first="Juan" last="Fu">Juan Fu</name><affiliation wicri:level="1"><nlm:aff id="af2-ol-0-0-10797">State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, Guangdong 510060</wicri:regionArea><wicri:noRegion>Guangdong 510060</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-ol-0-0-10797">Department of Ultrasonography, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Ultrasonography, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060</wicri:regionArea><wicri:noRegion>Guangdong 510060</wicri:noRegion></affiliation></author><author><name sortKey="Huang, Jinsheng" sort="Huang, Jinsheng" uniqKey="Huang J" first="Jinsheng" last="Huang">Jinsheng Huang</name><affiliation wicri:level="1"><nlm:aff id="af2-ol-0-0-10797">State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangzhou, Guangdong 510060</wicri:regionArea><wicri:noRegion>Guangdong 510060</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af3-ol-0-0-10797">Department of General Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of General Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060</wicri:regionArea><wicri:noRegion>Guangdong 510060</wicri:noRegion></affiliation></author><author><name sortKey="Weng, Chengyin" sort="Weng, Chengyin" uniqKey="Weng C" first="Chengyin" last="Weng">Chengyin Weng</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-10797">Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180</wicri:regionArea><wicri:noRegion>Guangdong 510180</wicri:noRegion></affiliation></author><author><name sortKey="Fang, Xisheng" sort="Fang, Xisheng" uniqKey="Fang X" first="Xisheng" last="Fang">Xisheng Fang</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-10797">Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180</wicri:regionArea><wicri:noRegion>Guangdong 510180</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Mingmei" sort="Guan, Mingmei" uniqKey="Guan M" first="Mingmei" last="Guan">Mingmei Guan</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-10797">Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180</wicri:regionArea><wicri:noRegion>Guangdong 510180</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Yong" sort="Wu, Yong" uniqKey="Wu Y" first="Yong" last="Wu">Yong Wu</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-10797">Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180</wicri:regionArea><wicri:noRegion>Guangdong 510180</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Lin" sort="Yang, Lin" uniqKey="Yang L" first="Lin" last="Yang">Lin Yang</name><affiliation wicri:level="1"><nlm:aff id="af5-ol-0-0-10797">Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515</wicri:regionArea><wicri:noRegion>Guangdong 510515</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Guolong" sort="Liu, Guolong" uniqKey="Liu G" first="Guolong" last="Liu">Guolong Liu</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-0-0-10797">Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medical Oncology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180</wicri:regionArea><wicri:noRegion>Guangdong 510180</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oncology Letters</title><idno type="ISSN">1792-1074</idno><idno type="eISSN">1792-1082</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Neuron-specific enolase (NSE) is generally considered as a marker for diagnosis and evaluation of the response to therapy in small cell lung cancer (SCLC). However, the role of NSE in the progression of SCLC remains to be elucidated. In the present study, the functions of NSE in SCLC, in addition to the potential mechanisms, were investigated using a loss-of-function approach with NSE-targeting small interfering (si)RNA. The knockdown of NSE markedly decreased the proliferation of NCI-H209 cells, as indicated by MTT assay (P<0.05). Furthermore, the silencing of NSE resulted in the formation of smaller and fewer colonies compared with that in the control group (P<0.001). Flow cytometric analysis indicated that the silencing of NSE resulted in a decreased S-phase population among NCI-H209 cells (P<0.05). Transwell assay demonstrated that the silencing of NSE suppressed the migration of NCI-H209 cells (P<0.001). NCI-H209 cells transfected with NSE siRNA-1 or negative control were collected and the protein levels of metastasis-associated genes were detected using western blot analysis. The results indicated that the knockdown of NSE led to downregulation of the pro-metastatic gene vascular endothelial growth factor (VEGF; P<0.05) and the upregulation of metastasis suppressor genes NM23 and E-cadherin (P<0.05). Taken together, the results of the present study demonstrated that the silencing of NSE suppressed the migration, proliferation and colony formation ability of SCLC cells and decreased the S-phase population. In addition, the knockdown of NSE resulted in the upregulation of E-cadherin and NM23 and the downregulation of VEGF. Collectively, these results indicated that intracellular NSE may have an important role in the progression of SCLC.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Soerjomataram, I" uniqKey="Soerjomataram I">I Soerjomataram</name></author><author><name sortKey="Dikshit, R" uniqKey="Dikshit R">R Dikshit</name></author><author><name sortKey="Eser, S" uniqKey="Eser S">S Eser</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author><author><name sortKey="Rebelo, M" uniqKey="Rebelo M">M Rebelo</name></author><author><name sortKey="Parkin, Dm" uniqKey="Parkin D">DM Parkin</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D Forman</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wistuba, Ii" 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uniqKey="Lee H">H Lee</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Xia" sort="Liu, Xia" uniqKey="Liu X" first="Xia" last="Liu">Xia Liu</name></noRegion><name sortKey="Fang, Xisheng" sort="Fang, Xisheng" uniqKey="Fang X" first="Xisheng" last="Fang">Xisheng Fang</name><name sortKey="Fu, Juan" sort="Fu, Juan" uniqKey="Fu J" first="Juan" last="Fu">Juan Fu</name><name sortKey="Fu, Juan" sort="Fu, Juan" uniqKey="Fu J" first="Juan" last="Fu">Juan Fu</name><name sortKey="Guan, Mingmei" sort="Guan, Mingmei" uniqKey="Guan M" first="Mingmei" last="Guan">Mingmei Guan</name><name sortKey="Huang, Jinsheng" sort="Huang, Jinsheng" uniqKey="Huang J" first="Jinsheng" last="Huang">Jinsheng Huang</name><name sortKey="Huang, Jinsheng" sort="Huang, Jinsheng" uniqKey="Huang J" first="Jinsheng" last="Huang">Jinsheng Huang</name><name sortKey="Liu, Guolong" sort="Liu, Guolong" uniqKey="Liu G" first="Guolong" last="Liu">Guolong Liu</name><name sortKey="Liu, Shousheng" sort="Liu, Shousheng" uniqKey="Liu S" first="Shousheng" last="Liu">Shousheng Liu</name><name sortKey="Liu, Shousheng" sort="Liu, Shousheng" uniqKey="Liu S" first="Shousheng" last="Liu">Shousheng Liu</name><name sortKey="Weng, Chengyin" sort="Weng, Chengyin" uniqKey="Weng C" first="Chengyin" last="Weng">Chengyin Weng</name><name sortKey="Wu, Yong" sort="Wu, Yong" uniqKey="Wu Y" first="Yong" last="Wu">Yong Wu</name><name sortKey="Yang, Lin" sort="Yang, Lin" uniqKey="Yang L" first="Lin" last="Yang">Lin Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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